Overview: Report of a Scientific Working Group on Serious Adverse Events following Mectizan® treatment of onchocerciasis in Loa loa endemic areas.
نویسنده
چکیده
This report reviews information on Serious Adverse Events (SAE), mainly Loa-encephalopathy, following treatment with ivermectin (Mectizan®, Merck, Sharpe & Dohme) for control of onchocerciasis carried out by the African Programme for Onchocerciasis Control (APOC), in areas where heavy microfilarial infections with Loa loa are coendemic with Onchocerca volvulus infections. It also endeavours to define the information and research needed to understand, prevent, and manage cases of Loaencephalopathy.
منابع مشابه
Report of a Scientific Working Group on Serious Adverse Events following Mectizan® treatment of onchocerciasis in Loa loa endemic areas
The occurrence of Serious Adverse Experiences (SAEs) following Mectizan(R) treatment of onchocerciasis in Loa loa endemic areas has been increasingly reported over the past decade. These SAEs include a severely disabling, and potentially fatal, encephalopathy, which appears to correlate with a high load of L. loa microfilariae (> 30,000 mf/ml).Previous consultations organized by the Mectizan(R)...
متن کاملEncephalopathy Related to Ivermectin Treatment of Onchocerciasis in Loa loa Endemic Areas: Operational Considerations
Human onchocerciasis is a public health problem and an obstacle to socioeconomic development in endemic countries of Africa, Arabian Peninsula and South America (WHO, 1995). The community-directed treatment with ivermectin (CDTI) is the main strategy adopted by the African Programme for Onchocerciasis control (APOC). Severe adverse events with encephalopathy (SAEs) have been associated with mas...
متن کاملProgrammatic and Communication Issues in Relation to Serious Adverse Events Following Ivermectin Treatment in areas Co-endemic for Onchocerciasis and Loiasis
In areas co-endemic for loiasis and onchocerciasis, the classic Community-Directed Treatment using ivermectin (Mectizan(R)) must be adapted as additional program activities, better communication and tighter control of ivermectin stocks are required to minimize risk and manage serious adverse events following ivermectin treatment in patients co-infected with Loa loa. The importance of these seri...
متن کاملA Framework for Decision-Making for Mass Distribution of Mectizan® in Areas Endemic for Loa loa
BACKGROUND: The occurrence of Loa loa encephalopathy following mass treatment of onchocerciasis with Mectizan(R) has adversely affected onchocerciasis control efforts in central Africa. Persons with very high densities of L. loa microfilaremia are at increased risk of encephalopathy, but little is known about the geographic distribution of these persons within central Africa. RAPLOA, a new tech...
متن کاملGenetic heterogeneity in Loa loa parasites from southern Cameroon: A preliminary study
Ivermectin (or Mectizan trade mark ) is widely used by onchocerciasis and lymphatic filariasis control programs worldwide. Generally, Mectizan trade mark is both safe and well tolerated. An exception to this general pattern is in some areas co-endemic for Onchocerca volvulus and Loa loa, where a number of severe adverse reactions to Mectizan trade mark have been noted in L. loa infected individ...
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عنوان ژورنال:
- Filaria Journal
دوره 2 شماره
صفحات -
تاریخ انتشار 2003